Cancer BiologybioRxiv
Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1
A. Schwarzer, M. Oliveira, M.-J. Kleppa…·M. J. Kostura
This study identifies OMA1 activators that induce apoptosis in DLBCL cells via the ATF4-ISR pathway, showing efficacy in preclinical models.
DOI 10.1158/1535-7163.mct-22-0718