Author

A. Kotlyarov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:development & morphogenesis· 2 Assay:proteomics· 2

Frequent Co-Authors

M. Gaestel· 6 shared C. Chauhan· 2 shared M. B. Menon· 2 shared M. Soulez· 2 shared N. Ronkina· 2 shared S. Meloche· 2 shared A. Anantha· 1 shared A. Cooper· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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6 shared papersCell Biology

M. Gaestel

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

5-iodotubercidin sensitizes cells to RIPK1-dependent necroptosis by interfering with NFkappaB signaling

C. Chauhan, A. Kraemer, S. Knapp, M. Windheim, A. Kotlyarov, M. B. Menon, M. Gaestel

This study identifies 5-iodotubercidin as a compound that sensitizes cells to RIPK1-dependent necroptosis by inhibiting NFκB signaling in MK2-deficient cells.

bioRxiv · Mar 3, 2023Cell Biology

On the therapeutic potential of MAPK4 in triple-negative breast cancer

F. Boudghene-Stambouli, M. Soulez, N. Ronkina, A. Doerrie, A. Kotlyarov, O.-M. Seternes, M. Gaestel, S. Meloche

The paper critiques Wang et al.'s study on ERK4's role in TNBC, arguing that methodological flaws undermine their conclusion that ERK4 is a therapeutic target.

bioRxiv · Aug 24, 2022 · PreprintCancer Biology

PRMT5-mediated regulatory arginine methylation of RIPK3

C. Chauhan, A. M. Del Val, R. Niedenthal, J. V. Olsen, A. Kotlyarov, S. Bekker-Jensen, M. Gaestel, M. B. Menon

This study identifies PRMT5-mediated arginine methylation of RIPK3 as a feedback mechanism regulating RIPK1 activity and function in cell death pathways.

bioRxiv · Aug 1, 2022Cell Biology

Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1

A. Schwarzer, M. Oliveira, M.-J. Kleppa, S. D. Slattery, A. Anantha, A. Cooper, M. Hannink, A. Schambach, A. Dorrie, A. Kotlyarov, M. Gaestel, T. Hembrough, J. Levine, M. Luther, M. Stocum, , M. J. Kostura

This study identifies OMA1 activators that induce apoptosis in DLBCL cells via the ATF4-ISR pathway, showing efficacy in preclinical models.

bioRxiv · Jun 12, 2022Cancer Biology

ERK3-MK5 signaling regulates myogenic differentiation and muscle regeneration by promoting FoxO3 degradation

M. Soulez, P.-L. Tanguay, F. Do, C. Crist, J. Dort, A. Kotlyarov, M. Gaestel, N. A. Dumont, S. Meloche

bioRxiv · Apr 29, 2021Cell Biology

Germline deletion reveals a non-essential role of the atypical MAPK6/ERK3

N. Ronkina, K. Schuster-Gossler, F. Hansmann, H. Kunze-Schumacher, I. Sandrock, T. Yakovleva, J. Lafera, W. Baumgärtner, A. Krueger, I. Prinz, A. Gossler, A. Kotlyarov, M. Gaestel

The paper shows that ERK3 is not essential for viability, fertility, or T-cell function, contradicting previous reports of perinatal lethality due to a different genetic construct.

bioRxiv · Nov 10, 2018Cell Biology