Author

M. J. Rale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:Xenopus· 2 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

S. Petry· 2 shared A. Thawani· 1 shared B. P. Mahon· 1 shared B. Romer· 1 shared G. Bhabha· 1 shared H. A. Stone· 1 shared J. W. Shaevitz· 1 shared N. Coudray· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

S. Petry

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2 papers

Recent·Most cited

The conserved centrosomal motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC).

M. J. Rale, B. Romer, B. P. Mahon, S. M. Travis, S. Petry

This study identifies γTuNA as a dimer that directly activates γTuRC to nucleate microtubules, opposing stathmin inhibition.

bioRxiv · Apr 11, 2022 · PreprintBiochemistry

The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy

A. Thawani, M. J. Rale, N. Coudray, G. Bhabha, H. A. Stone, J. W. Shaevitz, S. Petry

This study uses single molecule microscopy to reveal how γ-TuRC nucleates microtubules, showing a cooperative mechanism involving 4 β-tubulin dimers and the role of XMAP215 in enhancing nucleation efficiency.

bioRxiv · Jun 13, 2020Cell Biology