Author

M. J. Spindler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Bertero· 1 shared A. Gras· 1 shared A. H. Chan· 1 shared A. Kulkarni· 1 shared A. M. Fenix· 1 shared A. N. Hata· 1 shared A. R. Niedecken· 1 shared A. T. Ramjag· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCell Biology

A. Bertero

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Author profile →

3 papers

Recent·Most cited

Stitchr: stitching coding TCR nucleotide sequences from V/J/CDR3 information

J. M. Heather, M. J. Spindler, M. Herrero Alonso, Y. I. Shui, D. G. Millar, D. S. Johnson, M. Cobbold, A. N. Hata

Stitchr generates full-length coding TCR sequences from V/J/CDR3 information, validated through synthesis and transduction in Jurkat cells, enabling efficient TCR engineering and analysis.

bioRxiv · Dec 20, 2021Immunology

Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies

A. M. Fenix, Y. Miyaoka, A. Bertero, S. Blue, M. J. Spindler, K. K. B. Tan, J. A. Perez-Bermejo, A. H. Chan, S. J. Mayer, T. Nguyen, C. R. Russell, P. Lizarraga, A. Truong, P.-L. So, A. Kulkarni, , N. Salomonis

This study investigates how RBM20 mutations affect splicing and ribonucleoprotein granules in cardiomyopathy, revealing distinct pathogenic mechanisms between missense and knockout mutations.

bioRxiv · Jun 2, 2021Cell Biology

Capturing and Recreating Diverse Antibody Repertoires as Multivalent Recombinant Polyclonal Antibody Drugs

S. M. Keating, R. A. Mizrahi, M. S. Adams, M. A. Asensio, E. Benzie, K. P. Carter, Y. Chiang, R. C. Edgar, B. K. Gautam, A. Gras, J. Leong, R. Leong, Y. W. Lim, V. A. Manickam, A. V. Medina-Cucurella, , E Meyer

This paper demonstrates a technology to capture and recreate diverse antibody repertoires as multivalent recombinant drugs, showing applications against SARS-CoV-2, Zika virus, and graft-versus-host disease.

bioRxiv · Aug 5, 2020 · PreprintImmunology