N. Salomonis

A potential acoustic role for CFTR ion channel in conductive hearing loss

This study investigates the role of CFTR in conductive hearing loss by analyzing middle ear cell composition and gene expression in CF and WT mice.

Temporal dynamics and genomic programming of plasma cell fates

This study identifies a novel PC transition state and shows that long-lived plasma cells arise from late-phase GC responses through TIGIT-dependent clonal expansion.

Balance between protective and pathogenic immune responses to pneumonia in the neonatal lung enforced by gut microbiota.

The paper shows that gut microbiota balance immune responses in neonatal lungs, promoting recovery from pneumonia by modulating tissue repair and inflammation.

Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies

This study investigates how RBM20 mutations affect splicing and ribonucleoprotein granules in cardiomyopathy, revealing distinct pathogenic mechanisms between missense and knockout mutations.

A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation

This study investigates the fetal lung immune response to intra-uterine inflammation in Rhesus macaques, finding a rapid myeloid cell activation and cytokine-driven inflammation.

Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers

The paper uses snRNA-seq to analyze transcriptional diversity in multinucleated skeletal myofibers, revealing distinct myonuclear populations and novel gene markers.

Three-dimensional mapping identifies distinct vascular niches for myelopoiesis

This paper maps 3D vascular niches for myeloid differentiation in bone marrow, revealing distinct spatial organization of granulocyte and monocyte/dendritic cell progenitors.

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

This study shows that intermittent hypoxia in mice alters gene expression in lung cells, particularly in endothelial cells, linking it to pulmonary fibrosis and hypertension pathways.