D. S. Johnson

NaV1.7 targeted fluorescence imaging agents for nerve identification during intraoperative procedures

This paper develops fluorescent imaging agents targeting NaV1.7 to improve nerve visualization during surgery, demonstrating effectiveness in non-human primates.

A range expanding ecosystem engineer influences historical and expanded habitats via the same causal pathways

This study examines how the range-expanding mud fiddler crab influences ecosystem functioning in both historical and expanded habitats, finding similar causal pathways in both.

Estimating Northern Fur Seal Pup Production: A case study of batch mark abundance estimation

This paper develops and evaluates a hierarchical N-mixture model for estimating northern fur seal pup production using batch mark-resight data, showing that Gaussian approximations can provide reliable estimates with reduced uncertainty.

Stitchr: stitching coding TCR nucleotide sequences from V/J/CDR3 information

Stitchr generates full-length coding TCR sequences from V/J/CDR3 information, validated through synthesis and transduction in Jurkat cells, enabling efficient TCR engineering and analysis.

Lack of blocking activity in anti-CTLA-4 antibodies reduces toxicity, but not anti-tumor efficacy

This study shows that anti-CTLA-4 antibodies with reduced checkpoint inhibition have better anti-tumor efficacy and lower toxicity by primarily depleting tumor-infiltrating Tregs via FcR signaling.

Cargo modulates the conformation of the nuclear pore in living cells

The paper shows that specific NPC components change conformation when interacting with cargo in living cells.

A Continuous-Time Semi-Markov Model for Animal Movement in a Dynamic Environment

The paper develops a continuous-time semi-Markov model for animal movement, showing wind and currents influence fur seal pups' movement more than sea surface temperature.

Timing of ESCRT-III protein recruitment and membrane scission during HIV-1 assembly

The paper observes ESCRT-III recruitment and timing during HIV-1 membrane scission, showing they arrive after membrane bending and depart before scission.

Confronting preferential sampling in wildlife surveys: diagnosis and model-based triage

This paper develops a hierarchical model to detect and correct preferential sampling bias in wildlife surveys, showing it reduces density estimation bias in simulated and real data.