Author

M. J. W. Sim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Organism:mouse· 1

Frequent Co-Authors

E. O. Long· 5 shared P. D. Sun· 4 shared J. Lu· 3 shared P. Brennan· 3 shared S. Rajagopalan· 3 shared D. M. Altmann· 2 shared R. J. Boyton· 2 shared A. Khan· 1 shared

Activity by Year

2016-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersImmunology

E. O. Long

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Identification and Structural Characterization of a mutant KRAS-G12V specific TCR restricted by HLA-A3

M. J. W. Sim, K.-i. Hanada, Z. S. Stotz, Z. Yu, J. Lu, P. Brennan, M. Quastel, G. Gillespie, E. O. Long, J. C. Yang, P. D. Sun

The paper identifies a TCR specific to KRAS-G12V neoantigen and characterizes its structural interaction with HLA-A3, revealing challenges in targeting this mutation.

bioRxiv · Feb 1, 2024Immunology

Innate receptors with high specificity for HLA class I-peptide complexes

M. J. W. Sim, P. Brennan, K. L. Wahl, J. Lu, S. Rajagopalan, P. D. Sun, E. O. Long

The paper identifies peptide-specific binding of KIR receptors to HLA class I complexes, revealing differences in specificity between inhibitory and activating KIRs.

bioRxiv · Feb 6, 2023Immunology

T cells discriminate between groups C1 and C2 HLA-C

M. J. W. Sim, Z. Stotz, J. Lu, P. Brennan, E. O. Long, P. D. Sun

This study shows that T cells can distinguish between C1 and C2 HLA-C groups due to differences in peptide presentation and TCR affinity.

bioRxiv · Nov 11, 2021Immunology

HLA-C-restricted presentation of a conserved bacterial epitope to an innate NK cell receptor

M. J. W. Sim, S. Rajagopalan, D. M. Altmann, R. J. Boyton, P. D. Sun, E. O. Long

This study identifies a conserved bacterial epitope recognized by HLA-C*05:01 and the NK cell receptor KIR2DS4, suggesting a novel role for NK cells in detecting bacteria.

bioRxiv · Feb 15, 2019Immunology

Canonical and cross-reactive binding of NK cell inhibitory receptors to HLA-C allotypes is dictated by peptides bound to HLA-C

M. J. W. Sim, S. A. Malaker, A. Khan, J. M. Stowell, J. Shabanowitz, M. E. Peterson, S. Rajagopalan, D. F. Hunt, D. M. Altmann, E. O. Long, R. J. Boyton

This study shows that HLA-C bound peptides influence KIR binding specificity, with KIR2DL1 showing broader peptide tolerance than KIR2DL2/3, and cross-reactive binding being highly peptide selective.

bioRxiv · Dec 27, 2016Immunology