Author

E. O. Long

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 9

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 7 Assay:proteomics· 7 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. J. W. Sim· 5 shared S. Rajagopalan· 5 shared P. D. Sun· 4 shared B. Traore· 3 shared J. Lu· 3 shared P. Brennan· 3 shared P. D. Crompton· 3 shared D. M. Altmann· 2 shared

Activity by Year

2016-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersImmunology

M. J. W. Sim

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Author profile →

9 papers

Recent·Most cited

Identification and Structural Characterization of a mutant KRAS-G12V specific TCR restricted by HLA-A3

M. J. W. Sim, K.-i. Hanada, Z. S. Stotz, Z. Yu, J. Lu, P. Brennan, M. Quastel, G. Gillespie, E. O. Long, J. C. Yang, P. D. Sun

The paper identifies a TCR specific to KRAS-G12V neoantigen and characterizes its structural interaction with HLA-A3, revealing challenges in targeting this mutation.

bioRxiv · Feb 1, 2024Immunology

NK cell-induced damage to P. falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG

P. Sekar, S. Rajagopalan, E. Shabani, U. Kanjee, M. Schurek, G. Arora, M. E. Peterson, B. Traore, P. D. Crompton, M. T. Duraisingh, S. A. Desai, E. O. Long

This study shows NK cells lyse P. falciparum-infected erythrocytes via ADCC, releasing parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG.

bioRxiv · Jul 31, 2023 · PreprintImmunology

Functional genomics identifies extension of complex N-glycans as a mechanism to evade lysis by natural killer cells

X. Zhuang, J. Woods, Y. Ji, S. Scheich, F. Mo, M. Voss, H. Urlaub, K.-T. Pan, E. O. Long

The paper identifies SPPL3 as a gene that enables tumor cells to evade NK cell lysis by altering N-glycan structures, and shows that inhibiting N-glycan maturation restores NK sensitivity.

bioRxiv · Apr 3, 2023 · PreprintImmunology

Innate receptors with high specificity for HLA class I-peptide complexes

M. J. W. Sim, P. Brennan, K. L. Wahl, J. Lu, S. Rajagopalan, P. D. Sun, E. O. Long

The paper identifies peptide-specific binding of KIR receptors to HLA class I complexes, revealing differences in specificity between inhibitory and activating KIRs.

bioRxiv · Feb 6, 2023Immunology

T cells discriminate between groups C1 and C2 HLA-C

M. J. W. Sim, Z. Stotz, J. Lu, P. Brennan, E. O. Long, P. D. Sun

This study shows that T cells can distinguish between C1 and C2 HLA-C groups due to differences in peptide presentation and TCR affinity.

bioRxiv · Nov 11, 2021Immunology

Plasmodium falciparum-specific IgM B cells dominate in children, expand with malaria and produce parasite inhibitory IgM

C. Hopp, A. Diouf, K. Miura, K. Boswell, P. Sekar, J. Skinner, C. M. Tipton, M. Chambers, S. Andrews, J. Tan, S. Li, S. Doumbo, K. Kayentao, A. Ongoiba, B. Traore, , P. D. Crompton

The paper identifies Pf-specific IgM B cells in children, showing they expand during malaria and produce inhibitory IgM antibodies.

bioRxiv · Apr 12, 2020Immunology

HLA-C-restricted presentation of a conserved bacterial epitope to an innate NK cell receptor

M. J. W. Sim, S. Rajagopalan, D. M. Altmann, R. J. Boyton, P. D. Sun, E. O. Long

This study identifies a conserved bacterial epitope recognized by HLA-C*05:01 and the NK cell receptor KIR2DS4, suggesting a novel role for NK cells in detecting bacteria.

bioRxiv · Feb 15, 2019Immunology

NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody dependent cellular cytotoxicity

G. Arora, G. T. Hart, J. Manzella-Lapeira, J. Y. A. Doritchamou, D. L. Narum, M. Thomas, J. Brzostowski, S. Rajagopalan, O. K. Doumbo, B. Traore, L. Miller, S. K. Pierce, P. Duffy, P. D. Crompton, S. A. Desai, E. O. Long

The paper shows that antibodies from malaria-exposed individuals activate NK cells to lyse infected red blood cells and inhibit parasite growth via ADCC.

bioRxiv · Mar 29, 2018Immunology

Canonical and cross-reactive binding of NK cell inhibitory receptors to HLA-C allotypes is dictated by peptides bound to HLA-C

M. J. W. Sim, S. A. Malaker, A. Khan, J. M. Stowell, J. Shabanowitz, M. E. Peterson, S. Rajagopalan, D. F. Hunt, D. M. Altmann, E. O. Long, R. J. Boyton

This study shows that HLA-C bound peptides influence KIR binding specificity, with KIR2DL1 showing broader peptide tolerance than KIR2DL2/3, and cross-reactive binding being highly peptide selective.

bioRxiv · Dec 27, 2016Immunology