Author

S. Rajagopalan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 5 Microbiology· 2 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 6 Organism:human· 5 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

E. O. Long· 5 shared M. J. W. Sim· 3 shared B. Traore· 2 shared D. M. Altmann· 2 shared G. Arora· 2 shared M. E. Peterson· 2 shared P. D. Crompton· 2 shared P. D. Sun· 2 shared

Activity by Year

2016-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersImmunology

E. O. Long

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Defining ancestry, heritability and plasticity of cellular phenotypes in somatic evolution

J. S. Schiffman, A. R. D'Avino, T. Prieto, Y. Pang, Y. Fan, S. Rajagopalan, C. Potenski, T. Hara, M. L. Suva, C. Gawad, D. A. Landau

The paper introduces PATH, a framework to quantify heritability and plasticity of cellular phenotypes in somatic evolution using single-cell data from mouse and human samples.

Nature Genetics · Sep 24, 2024Peer-reviewedEvolutionary Biology

The PDIM paradox of Mycobacterium tuberculosis: new solutions to a persistent problem

C. V. Mulholland, T. J. Wiggins, J. Cui, C. Vilcheze, S. Rajagopalan, M. W. Shultis, E. Z. Reyes-Fernandez, W. R. Jacobs, M. Berney

The paper identifies a metabolic deficiency causing PDIM loss in Mycobacterium tuberculosis and shows how nutrient supplementation can restore PDIM production and virulence.

bioRxiv · Oct 16, 2023Microbiology

NK cell-induced damage to P. falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG

P. Sekar, S. Rajagopalan, E. Shabani, U. Kanjee, M. Schurek, G. Arora, M. E. Peterson, B. Traore, P. D. Crompton, M. T. Duraisingh, S. A. Desai, E. O. Long

This study shows NK cells lyse P. falciparum-infected erythrocytes via ADCC, releasing parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG.

bioRxiv · Jul 31, 2023 · PreprintImmunology

The SapM phosphatase arrests phagosome maturation in an ESX-1 independent manner in Mycobacterium tuberculosis and BCG

C. Xander, S. Rajagopalan, W. R. Jacobs, M. Braunstein

This study shows SapM phosphatase induces phagosome maturation arrest in Mycobacterium tuberculosis and BCG without requiring the ESX-1 secretion system.

bioRxiv · Feb 13, 2023Microbiology

Innate receptors with high specificity for HLA class I-peptide complexes

M. J. W. Sim, P. Brennan, K. L. Wahl, J. Lu, S. Rajagopalan, P. D. Sun, E. O. Long

The paper identifies peptide-specific binding of KIR receptors to HLA class I complexes, revealing differences in specificity between inhibitory and activating KIRs.

bioRxiv · Feb 6, 2023Immunology

Adipocyte lipolysis abrogates skin fibrosis in a Wnt/DPP4-dependent manner

A. R. Jussila, E. Caves, B. Zhang, S. Kirti, M. Steele, V. Lei, E. Hamburg-Shields, J. Lydon, Y. Ying, R. Lafyatis, S. Rajagopalan, V. Horsley, R. P. Atit

This study shows that adipocyte lipolysis, regulated by Wnt signaling and DPP4, reduces skin fibrosis by modulating ECM homeostasis.

bioRxiv · Jan 21, 2021 · PreprintCell Biology

HLA-C-restricted presentation of a conserved bacterial epitope to an innate NK cell receptor

M. J. W. Sim, S. Rajagopalan, D. M. Altmann, R. J. Boyton, P. D. Sun, E. O. Long

This study identifies a conserved bacterial epitope recognized by HLA-C*05:01 and the NK cell receptor KIR2DS4, suggesting a novel role for NK cells in detecting bacteria.

bioRxiv · Feb 15, 2019Immunology

NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody dependent cellular cytotoxicity

G. Arora, G. T. Hart, J. Manzella-Lapeira, J. Y. A. Doritchamou, D. L. Narum, M. Thomas, J. Brzostowski, S. Rajagopalan, O. K. Doumbo, B. Traore, L. Miller, S. K. Pierce, P. Duffy, P. D. Crompton, S. A. Desai, E. O. Long

The paper shows that antibodies from malaria-exposed individuals activate NK cells to lyse infected red blood cells and inhibit parasite growth via ADCC.

bioRxiv · Mar 29, 2018Immunology

Canonical and cross-reactive binding of NK cell inhibitory receptors to HLA-C allotypes is dictated by peptides bound to HLA-C

M. J. W. Sim, S. A. Malaker, A. Khan, J. M. Stowell, J. Shabanowitz, M. E. Peterson, S. Rajagopalan, D. F. Hunt, D. M. Altmann, E. O. Long, R. J. Boyton

This study shows that HLA-C bound peptides influence KIR binding specificity, with KIR2DL1 showing broader peptide tolerance than KIR2DL2/3, and cross-reactive binding being highly peptide selective.

bioRxiv · Dec 27, 2016Immunology