Mapping the landscape of genetic dependencies in chordoma
T. Sharifnia, M. J. Wawer, A. Goodale, Y. Lee, M. Kazachkova, J. M. Dempster, S. Muller, J. Levy, D. M. Freed, J. Sommer, J. Kalfon, F. Vazquez, W. C. Hahn, D. E. Root, P. A. Clemons, S. L. Schreiber
This study identifies essential genes in chordoma using CRISPR screens, revealing new therapeutic targets like PTPN11 and confirming known dependencies such as TBXT.
bioRxiv · Aug 17, 2022Cancer Biology