Author

M. Kazachkova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:CRISPR screen· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

D. E. Root· 3 shared F. Vazquez· 2 shared J. M. Dempster· 2 shared J. M. McFarland· 2 shared M. Abdusamad· 2 shared T. R. Golub· 2 shared W. C. Hahn· 2 shared A. Asfaw· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

D. E. Root

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mapping the landscape of genetic dependencies in chordoma

T. Sharifnia, M. J. Wawer, A. Goodale, Y. Lee, M. Kazachkova, J. M. Dempster, S. Muller, J. Levy, D. M. Freed, J. Sommer, J. Kalfon, F. Vazquez, W. C. Hahn, D. E. Root, P. A. Clemons, S. L. Schreiber

This study identifies essential genes in chordoma using CRISPR screens, revealing new therapeutic targets like PTPN11 and confirming known dependencies such as TBXT.

bioRxiv · Aug 17, 2022Cancer Biology

Phosphate dysregulation via the XPR1:KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer

D. P. Bondeson, B. R. Paolella, A. Asfaw, M. Rothberg, T. Skipper, C. Langan, A. Gonzalez, L. Surface, K. Ito, M. Kazachkova, W. N. Colgan, A. Warren, J. Dempster, J. M. Krill-Burger, M. Ericcson, , T. R. Golub

The paper identifies XPR1 and KIDINS220 as therapeutic targets in ovarian cancer by showing their role in phosphate dysregulation leading to cell death.

bioRxiv · Oct 16, 2020Cancer Biology

Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint

Y. Cohen-Sharir, J. M. McFarland, M. Abdusamad, C. Marquis, H. Tang, M. R. Ippolito, S. V. Bernhard, K. Laue, H. L. Malaby, A. Jones, M. Kazachkova, N. Lyons, A. Nagaraja, A. J. Bass, R. Beroukhim, , U. Ben-David

This study identifies aneuploid cancer cells as more vulnerable to spindle assembly checkpoint (SAC) inhibition and explores the underlying mechanisms.

bioRxiv · Jun 18, 2020Cancer Biology

Extracting Biological Insights from the Project Achilles Genome-Scale CRISPR Screens in Cancer Cell Lines

J. M. Dempster, J. Rossen, M. Kazachkova, J. Pan, G. Kugener, D. E. Root, A. Tsherniak

The paper describes updates to the Project Achilles processing pipeline for CRISPR screens in cancer cell lines, including quality control improvements and dependency score calculations.

bioRxiv · Jul 31, 2019 · PreprintCancer Biology