J. H. Shrimp

Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity

This study shows ivermectin reduces SARS-CoV-2 viral burden in vitro but at concentrations that also cause cytotoxicity, suggesting its antiviral effect may be due to nonspecific membrane perturbation rather than specific antiviral activity.

Reference compounds for characterizing cellular injury in high-content cellular morphology assays

The paper profiles 218 cytotoxic and nuisance compounds in U-2 OS cells to create reference compounds for improving assay optimization and compound prioritization in cellular morphology assays.

A Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19

The paper develops and validates a series of assays to identify TMPRSS2 inhibitors as potential COVID-19 treatments, identifying six compounds with varying clinical statuses.

An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19

The paper describes an enzymatic TMPRSS2 assay for inhibitor discovery and profiling of FDA-approved therapeutics, showing varying potencies of tested compounds.

Real-time sharing of drug screening data on the NCATS OpenData Portal accelerates translational research

This paper describes the NCATS OpenData Portal, a platform for real-time sharing of drug screening data that accelerates translational research by enabling immediate access to large-scale datasets.

A chemoproteomic portrait of the oncometabolite fumarate

This study maps fumarate's covalent targets using chemoproteomic probes and identifies cysteine residues affected by fumarate or FH mutations in HLRCC cells.

Chemical control of a CRISPR-Cas9 acetyltransferase

The paper develops a CRISPR-Cas9-based tool to study acetylation-dependent gene expression and identifies small molecule inhibitors of p300 activity.