Author

M. Jefferson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

T. Wileman· 3 shared U. Mayer· 2 shared Y. Wang· 2 shared A. Kipar· 1 shared A. Mann· 1 shared A. Zhekova· 1 shared B. Bone· 1 shared C. Morris· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

T. Wileman

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3 papers

Recent·Most cited

The WD Domain Of Atg16l1 Crucial For LC3-Associated Phagocytosis Is Not Required For Preserving Skin Homeostasis In Mice

S. Conway, M. Jefferson, D. Warren, T. Wileman, C. Morris

This study investigates the role of Atg16l1 in skin homeostasis using LAP-deficient mice, finding no significant cutaneous phenotype despite histological differences.

bioRxiv · Oct 30, 2023 · PreprintCell Biology

TECPR1 provides E3-ligase like activity to the ATG5-ATG12 complex to conjugate LC3/ATG8 to damaged lysosomes

Y. Wang, M. Jefferson, J. Mccoll, P. Verkade, U. Mayer, T. Wileman

This study shows TECPR1 can substitute for ATG16L1 to conjugate LC3 to damaged lysosomes by providing E3-ligase activity to the ATG5-ATG12 complex.

bioRxiv · Jun 24, 2023 · PreprintCell Biology

The WD and linker domains of ATG16L1 required for non canonical autophagy limit lethal influenza A virus infection at epithelial surfaces.

Y. Wang, W. Zhang, M. Jefferson, P. Sharma, B. Bone, A. Kipar, J. L. Coombes, T. Pearson, A. Mann, A. Zhekova, Y. Bao, R. A. Tripp, Y. Yamauchi, S. R. Carding, U. Mayer, , T. Wileman

This study shows that non-canonical autophagy, mediated by the WD and linker domains of ATG16L1, protects against lethal influenza A virus infection by limiting viral replication and inflammation in airway epithelial cells.

bioRxiv · Jan 15, 2020 · PreprintMicrobiology