Y. Yamauchi

ABCA1 deficiency causes tissue-specific dysregulation of the SREBP2 pathway in mice

This study shows ABCA1 deficiency leads to tissue-specific SREBP2 pathway dysregulation in mice, depending on nutritional status, contributing to cholesterol deposition and atherosclerosis.

The α-dystroglycan N-terminus is a broad-spectrum antiviral agent against SARS-CoV-2 and enveloped viruses

This study shows that the N-terminal fragment of α-dystroglycan blocks SARS-CoV-2 and other enveloped viruses in cell culture and animal models.

Alternative cell entry mechanisms for SARS-CoV-2 and multiple animal viruses

This study identifies alternative cell entry mechanisms for SARS-CoV-2 and other viruses, showing some rely on dynamin while others use actin-dependent pathways.

Microbiome ssRNA as an environmental cue to activate TLR13-dependent tissue-protective programs in CD5Lhi hepatic macrophages

The paper shows that microbiome ssRNA activates TLR13 in hepatic macrophages to drive tissue-protective responses, leading to resistance against acute liver injury in Rnaset2-/- mice.

Downregulation of CYP7B1 caused by lipotoxicity associates with the progression of non-alcoholic steatohepatitis

This study shows that restoring CYP7B1 expression reduces NASH progression in mice, linking its downregulation to lipid and oxidative stress in the early stages of the disease.

Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist

This study identifies KSI-6666 as a pseudoirreversible S1PR1 antagonist that suppresses inflammation through interaction with a methionine residue.

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

This study identifies TLR7/8 as drivers of histiocytosis in SLC29A3 disorders by responding to lysosomal nucleoside stress and enhancing monocyte proliferation and phagocyte maturation.

Hydroxylation site-specific and production-dependent roles of endogenous oxysterols in cellular cholesterol homeostasis

This study investigates how endogenously synthesized oxysterols regulate cholesterol homeostasis by affecting SREBP-2 and LXR, showing site-specific and production-dependent effects.

ESCPE-1 Mediates Retrograde Endosomal Sorting of the SARS-CoV-2 Host Factor Neuropilin-1

The paper identifies Neuropilin-1 as a retrograde cargo of ESCPE-1 and shows ESCPE-1 mediates its trafficking, potentially facilitating SARS-CoV-2 infection.

Skeletal muscle releases extracellular vesicles with distinct protein and miRNA signatures that accumulate and function within the muscle microenvironment

This study identifies markers for skeletal muscle-derived extracellular vesicles (SkM-EVs) and shows they mainly function within the muscle microenvironment rather than contributing significantly to plasma EVs.

A method for the generation of pseudotyped virus particles bearing SARS coronavirus spike protein in high yields

This paper describes an improved method to produce SARS-CoV and SARS-CoV-2 Spike protein pseudotyped VSV particles for coronavirus entry studies and antiviral development.

IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay

This study identifies a novel interaction between Regnase-1 and 14-3-3 mediated by IRAK1 that stabilizes inflammatory mRNAs by inhibiting Regnase-1 activity.

Neuropilin-1 is a host factor for SARS-CoV-2 infection

This study shows that SARS-CoV-2's S1 protein binds to NRP1 via the CendR motif, enhancing infection and identifying NRP1 as a therapeutic target.

The WD and linker domains of ATG16L1 required for non canonical autophagy limit lethal influenza A virus infection at epithelial surfaces.

This study shows that non-canonical autophagy, mediated by the WD and linker domains of ATG16L1, protects against lethal influenza A virus infection by limiting viral replication and inflammation in airway epithelial cells.

Nucleosides drive histiocytosis in SLC29A3 disorders by activating TLR7

This study shows that TLR7 activation by accumulated nucleosides in lysosomes drives histiocytosis in SLC29A3 disorders.