Ageing of the Upper Airway Epithelial Niche Limits Tissue-Resident T Cell Immunity
Wesley Huisman, Lisa A. King, Youvika Singh, Alicia C. de Kroon, Rosanne A. M. Steenbergen, Iris van der Valk, Renate S. Hagedoorn, Emile J. de Meijer, M. König, Tim Roek, Giovanni E. Loe-Sack-Sioe, Maurits T Wulffraat, Marjan J. T. van der Elst, Susan L. Kloet, Jutte J.C. de Vries, , Simon P. Jochems
This study shows that ageing reduces tissue-resident memory T cells in the upper airway, linked to impaired epithelial-immune crosstalk and reduced TGF-β signaling.
bioRxiv · Jul 16, 2026 · PreprintImmunology