Susan L. Kloet

The paper investigates how inflammation alters cell type-specific glucocorticoid responsiveness through single-cell RNA sequencing in zebrafish.

This study shows that ageing reduces tissue-resident memory T cells in the upper airway, linked to impaired epithelial-immune crosstalk and reduced TGF-β signaling.

This study identifies distinct transcriptional programs in human IgG4+ memory B cells, revealing unique features and potential therapeutic targets.

The paper characterizes a non-toxigenic C. difficile strain, L-NTCD03, showing antimicrobial resistance and non-toxicity, suggesting its potential as a live biotherapeutic.

The paper surveys Ruminococcus gnavus distribution across host lifestyles and health, revealing higher prevalence in Westernized populations and genomic differences between healthy and Crohn's disease isolates.

The paper investigates how PABPN1 loss-of-function in OPMD affects APA-shift in muscle transcripts, showing it is linked to reduced PABPN1 isoform expression rather than expanded PABPN1 levels.

The paper presents a long-read sequencing panel for pharmacogenomics, achieving high accuracy and phasing for SNVs and clinical star(*)-alleles.

This study compares NuRD's role in human and mouse pluripotent stem cells, finding that NuRD is required for transcriptional responses to differentiation signals in both, but with distinct functional differences between species.

The paper shows that MTA proteins in ES cell NuRD complex are functionally redundant, and NuRD is essential for maintaining differentiation trajectory during early lineage commitment.

The paper identifies GBAF as an enhancer-associated chromatin remodeler that interacts with H3K27ac and is essential for enhancer transcription.