Secretory cells are the primary source of pIgR in small airways
J. B. Blackburn, J. A. Schaff, S. Gutor, R.-H. Du, D. Nichols, T. Sherrill, A. J. Gutierrez, M. K. Xin, N. Wickersham, Y. Zhang, M. J. Holtzman, L. B. Ware, N. E. Banovich, J. A. Kropski, T. S. Blackwell, B. W. Richmond
The paper identifies secretory cells as the main source of pIgR in airways and shows reduced pIgR protein expression, not cell numbers, contributes to SIgA loss in COPD.
bioRxiv · Nov 10, 2021Cell Biology