Author

M. J. Holtzman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. P. Keeler· 3 shared K. Wu· 2 shared Y. Zhang· 2 shared A. G. Romero· 1 shared A. J. Gutierrez· 1 shared A. L. Bailey· 1 shared A. O. Hassan· 1 shared A. S. Kim· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

S. P. Keeler

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production

S. P. Keeler, K. Wu, Y. Zhang, D. Mao, M. Li, C. A. Iberg, S. R. Austin, S. A. Glaser, J. Yantis, S. Podgorny, S. L. Brody, J. R. Chartock, Z. Han, D. E. Byers, A. G. Romero, M. J. Holtzman

This paper develops a potent MAPK13-14 inhibitor, NuP-3, which reduces airway inflammation and mucus production in human airway models and minipig disease models.

bioRxiv · May 26, 2023Immunology

An alternative mechanism for skeletal muscle dysfunction in long-term post-viral lung disease

R. A. Martin, S. P. Keeler, K. Wu, W. J. Shearon, D. Patel, M. Hoang, C. M. Hoffmann, M. E. Hughes, M. J. Holtzman

This study identifies a distinct pattern of skeletal muscle dysfunction in a mouse model of long-term post-viral lung disease caused by Sendai virus, showing reduced myofiber size without changes in myofiber type or protein synthesis/degradation markers.

bioRxiv · Oct 7, 2022Physiology

Secretory cells are the primary source of pIgR in small airways

J. B. Blackburn, J. A. Schaff, S. Gutor, R.-H. Du, D. Nichols, T. Sherrill, A. J. Gutierrez, M. K. Xin, N. Wickersham, Y. Zhang, M. J. Holtzman, L. B. Ware, N. E. Banovich, J. A. Kropski, T. S. Blackwell, B. W. Richmond

The paper identifies secretory cells as the main source of pIgR in airways and shows reduced pIgR protein expression, not cell numbers, contributes to SIgA loss in COPD.

bioRxiv · Nov 10, 2021Cell Biology

A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection

A. O. Hassan, N. M. Kafai, I. P. Dmitriev, J. M. Fox, B. Smith, I. B. Harvey, R. E. Chen, E. S. Winkler, A. W. Wessel, J. B. Case, E. Kashentseva, B. T. McCune, A. L. Bailey, H. Zhao, L. A. VanBlargan, , M. S. Diamond

A single intranasal dose of ChAd-SARS-CoV-2-S vaccine prevents SARS-CoV-2 infection and likely confers sterilizing immunity in mice.

bioRxiv · Jul 16, 2020 · PreprintMicrobiology