Author

A. J. Gutierrez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Organism:human· 5 Research Focus:differential expression· 4 Assay:scRNA-seq· 4 Approach:experimental assay· 3 Research Focus:clustering· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

J. A. Kropski· 4 shared L. T. Bui· 4 shared C. J. Taylor· 3 shared N. E. Banovich· 3 shared A. C. Habermann· 2 shared B. W. Richmond· 2 shared I. O. Rosas· 2 shared J. B. Blackburn· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCell Biology

J. A. Kropski

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Author profile →

5 papers

Recent·Most cited

An integrated cell atlas of the human lung in health and disease

L. Sikkema, D. C. Strobl, L. Zappia, E. Madissoon, N. S. Markov, L.-E. Zaragosi, M. Ansari, M.-J. Arguel, L. Apperloo, C. Becavin, M. Berg, E. Chichelnitskiy, M.-i. Chung, A. Collin, A. C. Gay, , K. Travaglini

The paper integrates 46 single-cell datasets to create the Human Lung Cell Atlas, improving cell annotation and uncovering gene modules linked to demographics and anatomy.

bioRxiv · Mar 10, 2022Cell Biology

Secretory cells are the primary source of pIgR in small airways

J. B. Blackburn, J. A. Schaff, S. Gutor, R.-H. Du, D. Nichols, T. Sherrill, A. J. Gutierrez, M. K. Xin, N. Wickersham, Y. Zhang, M. J. Holtzman, L. B. Ware, N. E. Banovich, J. A. Kropski, T. S. Blackwell, B. W. Richmond

The paper identifies secretory cells as the main source of pIgR in airways and shows reduced pIgR protein expression, not cell numbers, contributes to SIgA loss in COPD.

bioRxiv · Nov 10, 2021Cell Biology

Single-cell transcriptomic assessment of cellular phenotype stability in human precision-cut lung slices

N. I. Winters, C. J. Taylor, C. S. Jetter, J. E. Camarata, A. J. Gutierrez, L. T. Bui, J. J. Gokey, M. Bacchetta, N. E. Banovich, J. M. S. Sucre, J. A. Kropski

The paper compares single-cell transcriptomic profiles of human PCLS after five days of culture to freshly isolated lung tissue, finding changes in endothelial and alveolar epithelial cell programs but stable immune cell profiles.

bioRxiv · Aug 19, 2021 · PreprintCell Biology

Integrated Single Cell Atlas of Endothelial Cells of the Human Lung

J. C. Schupp, T. S. Adams, C. Cosme, M. S. Brickman Raredon, N. Omote, S. Poli, K.-A. Rose, E. Manning, M. Sauler, G. DeIuliis, F. Ahangari, N. Neumark, Y. Yuan, A. C. Habermann, A. J. Gutierrez, , N. Kaminski

The paper reanalyzes six scRNA-seq datasets to create a comprehensive reference atlas of human lung endothelial cells, identifying new subpopulations and confirming their conservation in mice.

bioRxiv · Oct 21, 2020Cell Biology

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

L. T. Bui, N. I. Winters, M.-I. Chung, C. Joseph, A. J. Gutierrez, A. C. Habermann, T. S. Adams, J. C. Schupp, S. Poli, L. M. Peter, C. J. Taylor, J. B. Blackburn, B. W. Richmond, A. G. Nicholson, D. Rassl, , Human Cell Atlas Lung Biological Network

The paper analyzes single-cell transcriptomes from healthy and chronic lung disease lungs to identify gene expression programs linked to SARS-CoV-2 entry and severity.

bioRxiv · Oct 20, 2020Cell Biology