J. A. Kropski

Hypoxia-inducible factor-2 (HIF2) regulates alveolar regeneration after repetitive injury

Inhibiting hypoxia-inducible-factor 2 (HIF2) promotes functional lung alveolar epithelial repair following recurrent injury.

Epithelial Yap/Taz are required for functional alveolar regeneration following acute lung injury

This study shows that Yap/Taz in AT2 cells are essential for alveolar regeneration and preventing fibrosis after lung injury.

Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome

This study identifies intrinsic AT2 progenitor dysfunction and p53 pathway dysregulation as novel mechanisms driving pulmonary fibrosis in Hermansky-Pudlak syndrome.

Myeloid Cell-Derived IL1β Contributes to Pulmonary Vascular Remodeling in Heart Failure with Preserved Ejection Fraction

This study identifies myeloid cell-derived IL1β as a key driver of pulmonary vascular remodeling in HFpEF using a murine model and multi-omics approaches.

Alveolar repair following lipopolysaccharide-induced injury requires cell-extracellular matrix interactions

This study shows that β1-containing integrins are essential for alveolar repair after injury, as their absence leads to emphysema and impaired differentiation of AT2 cells into mature type 1 alveolar epithelial cells.

White Adipose Tissue Compositional and Transcriptional Patterns with Progressive Glucose Intolerance in Persons with HIV

The paper examines compositional and transcriptional changes in subcutaneous adipose tissue of HIV-positive individuals with varying glucose intolerance, identifying shared patterns with HIV-negative diabetics.

A Unique Cellular Organization of Human Distal Airways and Its Disarray in Chronic Obstructive Pulmonary Disease

This study identifies a unique epithelial cell population in human distal airways and shows its reduction in COPD, linked to IFN-gamma signaling.

Secretory cells are the primary source of pIgR in small airways

The paper identifies secretory cells as the main source of pIgR in airways and shows reduced pIgR protein expression, not cell numbers, contributes to SIgA loss in COPD.

Single-cell transcriptomic assessment of cellular phenotype stability in human precision-cut lung slices

The paper compares single-cell transcriptomic profiles of human PCLS after five days of culture to freshly isolated lung tissue, finding changes in endothelial and alveolar epithelial cell programs but stable immune cell profiles.

Integrated Single Cell Atlas of Endothelial Cells of the Human Lung

The paper reanalyzes six scRNA-seq datasets to create a comprehensive reference atlas of human lung endothelial cells, identifying new subpopulations and confirming their conservation in mice.

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

The paper analyzes single-cell transcriptomes from healthy and chronic lung disease lungs to identify gene expression programs linked to SARS-CoV-2 entry and severity.

Persistence of a novel regeneration-associated transitional cell state in pulmonary fibrosis

The paper identifies a novel transitional cell state in lung regeneration that exhibits senescence-like features and is enriched in fibrotic lung tissues, suggesting its role in pulmonary fibrosis pathogenesis.