Author

M. Karelina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Manglik· 1 shared A. S. Evers· 1 shared C.-M. Suomivuori· 1 shared D. F. Covey· 1 shared D. Regele· 1 shared D. S. Marks· 1 shared E. Stefan· 1 shared I. Deshpande· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

A. Manglik

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2 papers

Recent·Most cited

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway

N. Hoppe, S. Harrison, S.-H. Hwang, Z. Chen, M. Karelina, I. Deshpande, C.-M. Suomivuori, V. R. Palicharla, S. P. Berry, P. Tschaikner, D. Regele, D. F. Covey, E. Stefan, D. S. Marks, J. Reiter, , A. Manglik

The paper determines the cryo-EM structure of active GPR161 bound to Gs, revealing sterol binding and its role in ciliary cAMP signaling, while showing that sterol binding is not essential for Hedgehog pathway suppression.

Nature Structural & Molecular Biology · Feb 7, 2024Peer-reviewedBiochemistry

How accurately can one predict drug binding modes using AlphaFold models?

M. Karelina, J. J. Noh, R. Dror

This study evaluates how well AlphaFold 2 models predict drug binding modes to G protein-coupled receptors, finding improved pocket structure accuracy but limited ligand pose prediction improvements over traditional models.

bioRxiv · May 18, 2023 · PreprintBiophysics