S. Harrison

Global variation in the ratio of sapwood to leaf area explained by optimality principles

The paper explains 60% of global variation in sapwood-to-leaf area ratio using optimality principles linking plant hydraulics and photosynthesis.

Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex

The paper determines the crystal structure of a Cse4 peptide bound to the Okp1-Ame1 heterodimer in budding yeast, revealing key interactions essential for centromere recognition.

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway

The paper determines the cryo-EM structure of active GPR161 bound to Gs, revealing sterol binding and its role in ciliary cAMP signaling, while showing that sterol binding is not essential for Hedgehog pathway suppression.

Lack of detection of SARS-CoV-2 in British wildlife 2020-21 and first description of a stoat (Mustela erminea) Minacovirus

The paper tests British wildlife for SARS-CoV-2 and finds no infections but identifies a new minacovirus in stoats.

A prebiotic basis for ATP as the universal energy currency

This paper investigates the prebiotic chemistry of ATP, showing that acetyl phosphate could have driven protometabolism before ATP synthesis and that Fe3+ ions favor ADP phosphorylation to ATP.

A prevalent focused human antibody response to the influenza hemagglutinin head interface

The paper identifies a focused, protective antibody response targeting a conserved region at the influenza hemagglutinin head interface, showing cross-serotype binding and potential for durable immunity.

"Organoid-in-a-column" coupled on-line with liquid chromatography-mass spectrometry

This paper demonstrates the integration of liver organoids with liquid chromatography-mass spectrometry for on-line drug metabolism analysis.

Electromembrane extraction and mass spectrometry for liver organoid drug metabolism studies

This study demonstrates the use of electromembrane extraction (EME) combined with mass spectrometry to monitor drug metabolism in liver organoids.

Cryo-EM structure of full-length HIV-1 Env bound with the Fab of antibody PG16

The paper determines the cryo-EM structure of HIV-1 Env bound with antibody PG16 Fab, showing it stabilizes a closed conformation similar to SOSIP structures.

The structure of the yeast Ctf3 complex

The paper reports a near-atomic model of the yeast Ctf3 complex using cryo-EM, providing insights into its recruitment and function.

Clades of huge phage from across Earth’s ecosystems

The paper identifies major clades of large phage genomes across diverse ecosystems and highlights their expanded genetic repertoires and potential functional roles.