J. Reiter

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway

The paper determines the cryo-EM structure of active GPR161 bound to Gs, revealing sterol binding and its role in ciliary cAMP signaling, while showing that sterol binding is not essential for Hedgehog pathway suppression.

The cilia enriched oxysterol 7β,27-DHC is required for polycystin activation

This study identifies 7β,27-DHC as a critical oxysterol required for polycystin complex activation in cilia, revealing a lipid-mediated regulatory mechanism for ADPKD.

A ciliopathy complex builds distal appendages to initiate ciliogenesis

The paper identifies the DISCO complex, essential for ciliogenesis, and shows its role in distal appendage formation and centriole length regulation, linking defects to human ciliopathies.

A Human Accelerated Region is a Leydig cell GLI2 Enhancer that Affects Male-Typical Behavior

The paper identifies a human accelerated region (HAR) that functions as a Leydig cell enhancer for Gli2, affecting male-typical behavior in mice.

The primary cilium is required for MC4R control of food intake and body weight

This study shows that primary cilia on MC4R-expressing neurons are essential for MC4R's role in controlling food intake and body weight.

Zika virus alters centrosome organization to suppress the innate immune response

This study shows that Zika virus NS3 protein binds CEP63 to disrupt centrosome organization and suppress innate immune response by destabilizing TBK1.

Evolutionary Origins of Recurrent Pancreatic Cancer

This study identifies genetic features of recurrent pancreatic cancer through sequencing and finds that treatment-induced genetic changes and potential second primary tumors influence recurrence.

Feasibility of a surface-coated lung model for the quantification of active agent deposition for preclinical studies

The paper demonstrates a lung model for aerosol deposition analysis of antimicrobials without animal experiments, showing allicin's antibiotic effect and deposition pattern.