Author

S.-h. Hwang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

S. Mukhopadhyay· 2 shared V. R. Palicharla· 2 shared A. Manglik· 1 shared A. S. Evers· 1 shared B. N. Somatilaka· 1 shared C.-M. Suomivuori· 1 shared D. F. Covey· 1 shared D. Regele· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

S. Mukhopadhyay

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2 papers

Recent·Most cited

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway

N. Hoppe, S. Harrison, S.-H. Hwang, Z. Chen, M. Karelina, I. Deshpande, C.-M. Suomivuori, V. R. Palicharla, S. P. Berry, P. Tschaikner, D. Regele, D. F. Covey, E. Stefan, D. S. Marks, J. Reiter, , A. Manglik

The paper determines the cryo-EM structure of active GPR161 bound to Gs, revealing sterol binding and its role in ciliary cAMP signaling, while showing that sterol binding is not essential for Hedgehog pathway suppression.

Nature Structural & Molecular Biology · Feb 7, 2024Peer-reviewedBiochemistry

Interactions between TULP3 tubby domain cargo site and ARL13B amphipathic helix promote lipidated protein transport to cilia

V. R. Palicharla, S.-h. Hwang, B. N. Somatilaka, H. B. Badgandi, E. Legue, V. M. Tran, J. B. Woodruff, K. F. Liem, S. Mukhopadhyay

This study identifies how TULP3 interacts with ARL13B to transport lipidated and transmembrane proteins to cilia through specific binding motifs.

bioRxiv · May 25, 2021Cell Biology