M. Kinjo

Intracellular conformation of amyotrophic lateral sclerosis-causative TDP-43

This study uses FRET and FCS to analyze the conformation and interactions of TDP-43 in live cells, revealing structural changes in ALS-associated mutants.

Increased intracellular crowding during hyperosmotic stress

The paper uses FLIM and FCS to measure intracellular crowding changes during hyperosmotic stress and finds eGFP fluorescence lifetime and diffusion are early indicators of increased macromolecular crowding.

Short repeat RNA reduces cytotoxicity by preventing the aggregation of TDP-43 and its 25 kDa carboxy-terminal fragment

The paper identifies short RNA repeats that reduce TDP-43 and TDP25 aggregation and cytotoxicity without altering the transcriptome.

Interaction between spike protein of SARS-CoV-2 and human virus receptor ACE2 using two-color fluorescence cross-correlation spectroscopy

This study uses two-color fluorescence cross-correlation spectroscopy to analyze the interaction between SARS-CoV-2 S1 subunit and human ACE2, showing stronger binding of SARS-CoV-2 compared to SARS-CoV and one-to-one stoichiometry.

Molecular basis of functional compatibility between ezrin and other actin-membrane associated proteins during cytokinesis

This study investigates how ezrin interacts with actin-membrane proteins during cytokinesis, revealing differential compatibility in their binding sites and functional roles.