M. Mishra

Spaceflight alters host-gut microbiota interactions

This study identifies spaceflight-induced changes in gut microbiota and host gene expression in mice, suggesting altered host-microbiome interactions contribute to spaceflight-related pathologies.

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2

RMC-113 inhibits PIP4K2C and PIKfyve, reversing SARS-CoV-2-induced autophagic flux impairment and showing antiviral effects.

Regulation of apico-basolateral trafficking polarity of homologous Copper-ATPases ATP7A and ATP7B

This study identifies AP-1 isoforms as regulators of apico-basolateral trafficking polarity of ATP7A and ATP7B in polarized epithelia.

Tetraploidy-linked sensitization to CENP-E inhibition in human cells

This study shows that tetraploid cells are more sensitive to CENP-E inhibitors than diploid cells, leading to selective growth suppression through mitotic delay and cohesion fatigue.

Molecular basis of functional compatibility between ezrin and other actin-membrane associated proteins during cytokinesis

This study investigates how ezrin interacts with actin-membrane proteins during cytokinesis, revealing differential compatibility in their binding sites and functional roles.

Coarse-grained simulations of actomyosin rings point to a nodeless model involving both unipolar and bipolar myosins

The paper uses 3D coarse-grained simulations to test actomyosin ring models, finding that a nodeless arrangement with unipolar and bipolar myosins better matches experimental data than node-based models.

Structure of the fission yeast actomyosin ring during constriction

This study uses cryo-electron tomography to image the 3D structure of the actomyosin ring in fission yeast during cell division, revealing the arrangement of actin filaments.