R. Uehara

Fragility of ER homeostatic regulation underlies haploid instability in human somatic cells

This study identifies ER stress-induced proteotoxicity as a key factor causing haploid instability in human somatic cells, showing that haploids are more prone to apoptosis due to inefficient proteostasis.

Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells

This study examines the roles of ADD domains in DNMT3A and DNMT3L in DNA methylation in mouse germ cells, finding that their combined loss leads to severe methylation defects.

Tetraploidy-linked sensitization to CENP-E inhibition in human cells

This study shows that tetraploid cells are more sensitive to CENP-E inhibitors than diploid cells, leading to selective growth suppression through mitotic delay and cohesion fatigue.

Molecular basis of functional compatibility between ezrin and other actin-membrane associated proteins during cytokinesis

This study investigates how ezrin interacts with actin-membrane proteins during cytokinesis, revealing differential compatibility in their binding sites and functional roles.

Mevalonate pathway-mediated ER homeostasis is required for haploid stability in human somatic cells

This study shows that the mevalonate pathway regulates ER homeostasis, which is essential for maintaining haploid stability in human somatic cells.

Uncoupling of DNA replication and centrosome duplication cycles is a primary cause of haploid instability in mammalian somatic cells

This study shows that uncoupling DNA replication and centrosome duplication causes haploid instability in mammalian cells and demonstrates a method to restore coupling and improve stability.

Aicardi-Goutieres Syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer

This study identifies Rnaseh2c as a metastasis susceptibility gene in breast cancer, independent of its enzymatic activity, and links it to T cell-mediated immune responses.

Uncoordinated centrosome duplication cycle underlies the instability of non-diploid states in mammalian somatic cells

The paper shows that centrosome duplication cycle incompatibility with DNA replication causes instability in non-diploid mammalian somatic cells.