Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1
S. van Dorp, R. Qiu, U. B. Choi, M. M. Wu, M. Yen, M. Kirmiz, A. T. Brunger, R. S. Lewis
This study investigates the structural dynamics of STIM1's auto-inhibition mechanism using smFRET and crosslinking, revealing how CC1 interacts with CAD to regulate SOCE.
bioRxiv · Dec 17, 2020Biophysics