Author

M. Kooshkbaghi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

J. B. Kinney· 2 shared A. Ayaz· 1 shared A. R. Krainer· 1 shared A. Tareen· 1 shared B. E. Nickels· 1 shared C. Marti-Gomez· 1 shared C. Pukhrambam· 1 shared D. M. McCandlish· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

J. B. Kinney

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2 papers

Recent·Most cited

Specificity, synergy, and mechanisms of splice-modifying drugs

Y. Ishigami, M. S. Wong, C. Marti-Gomez, A. Ayaz, M. Kooshkbaghi, S. Hanson, D. M. McCandlish, A. R. Krainer, J. B. Kinney

This study develops quantitative models to understand how splice-modifying drugs work, showing drug-specific mechanisms and revealing widespread drug synergy and cooperativity.

bioRxiv · Dec 30, 2022Biophysics

Structural and mechanistic basis of σ-dependent transcriptional pausing

C. Pukhrambam, V. Molodtsov, M. Kooshkbaghi, A. Tareen, H. Vu, K. S. Skalenko, M. Su, Y. Zhou, J. T. Winkelman, J. B. Kinney, R. H. Ebright, B. E. Nickels

This paper identifies the structural basis of σ-dependent transcriptional pausing by showing that it involves backtracked or scrunched states of RNA polymerase, depending on the presence of GreB.

bioRxiv · Jan 24, 2022Biochemistry