Author

J. T. Winkelman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:E. coli· 2 Assay:ATAC-seq· 1 Organism:bacteria (other)· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. E. Nickels· 3 shared R. H. Ebright· 3 shared C. Pukhrambam· 2 shared D. M. Taylor· 2 shared I. O. Vvedenskaya· 2 shared J. B. Kinney· 2 shared K. S. Skalenko· 2 shared P. Shah· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBiochemistry

B. E. Nickels

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Author profile →

4 papers

Recent·Most cited

Combinatorial control of biofilm development by quorum-sensing and nutrient-sensing regulators in Pseudomonas aeruginosa

G. Chen, G. Fanouraki, A. Anandhi Rangarajan, B. T. Winkelman, J. T. Winkelman, C. M. Waters, S. Mukherjee

This study investigates how quorum-sensing and nutrient-sensing pathways in Pseudomonas aeruginosa interact to regulate biofilm formation, revealing a regulatory link through the small RNA CrcZ.

bioRxiv · Sep 27, 2022 · PreprintMicrobiology

Structural and mechanistic basis of σ-dependent transcriptional pausing

C. Pukhrambam, V. Molodtsov, M. Kooshkbaghi, A. Tareen, H. Vu, K. S. Skalenko, M. Su, Y. Zhou, J. T. Winkelman, J. B. Kinney, R. H. Ebright, B. E. Nickels

This paper identifies the structural basis of σ-dependent transcriptional pausing by showing that it involves backtracked or scrunched states of RNA polymerase, depending on the presence of GreB.

bioRxiv · Jan 24, 2022Biochemistry

Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli

K. S. Skalenko, L. Li, Y. Zhang, I. O. Vvedenskaya, J. T. Winkelman, A. Cope, D. M. Taylor, P. Shah, R. H. Ebright, J. B. Kinney, Y. Zhang, B. E. Nickels

The paper identifies promoter sequence determinants and structural basis of primer-dependent transcription initiation in E. coli using MASTER and biochemical studies.

bioRxiv · Apr 6, 2021Biochemistry

XACT-seq comprehensively defines the promoter-position and promoter-sequence determinants for initial-transcription pausing

J. T. Winkelman, C. Pukhrambam, I. O. Vvedenskaya, Y. Zhang, D. M. Taylor, P. Shah, R. H. Ebright, B. E. Nickels

XACT-seq identifies promoter-position and sequence determinants for initial-transcription pausing in Escherichia coli by measuring RNAP-active-center position relative to DNA with single-nucleotide resolution.

bioRxiv · Dec 21, 2019Biochemistry