The co-stimulatory activity of Tim-3 requires Akt and MAPK signaling and immune synapse recruitment
S. Kataoka, P. Manandhar, J. Lee, C. J. Workman, H. Banerjee, A. L. Szymczak-Workman, M. Kvorjak, J. Lohmueller, L. P. Kane
This study identifies Akt and MAPK signaling as essential for Tim-3 co-stimulatory activity and shows that Tim-3 localization to the immune synapse is critical for its function.
bioRxiv · Dec 30, 2019 · PreprintImmunology