Author

L. P. Kane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:CITE-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. L. Szymczak-Workman· 5 shared H. Banerjee· 2 shared A. Chang· 1 shared A. Kulkarni· 1 shared A. Montecalvo· 1 shared A. Piccirillo· 1 shared B. Murter· 1 shared C. J. Workman· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersImmunology

A. L. Szymczak-Workman

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Expression of Tim-3 drives naive Treg to an effector-like state with enhanced suppressive activity

H. Banerjee, H. Nieves-Rosado, A. Kulkarni, B. Murter, U. R. Chandran, A. Chang, A. L. Szymczak-Workman, L. Vujanovic, R. L. Ferris, L. P. Kane

The paper shows that Tim-3 expression in Treg cells drives them to an effector-like state with enhanced suppressive activity, promoting tumor growth.

bioRxiv · Jul 31, 2020 · PreprintImmunology

The co-stimulatory activity of Tim-3 requires Akt and MAPK signaling and immune synapse recruitment

S. Kataoka, P. Manandhar, J. Lee, C. J. Workman, H. Banerjee, A. L. Szymczak-Workman, M. Kvorjak, J. Lohmueller, L. P. Kane

This study identifies Akt and MAPK signaling as essential for Tim-3 co-stimulatory activity and shows that Tim-3 localization to the immune synapse is critical for its function.

bioRxiv · Dec 30, 2019 · PreprintImmunology

Polyubiquitin-dependent recruitment of NEMO/IKKγ into T cell receptor signaling microclusters

E. A. DeRiso, A. L. Szymczak-Workman, A. Montecalvo, J. M. Murphy, M.-C. Seminario, L. P. Kane, S. C. Bunnell

This study shows NEMO is recruited into TCR microclusters via polyubiquitin recognition domains, requiring Lck and ZAP-70 but not LAT or SLP-76.

bioRxiv · Apr 30, 2019 · PreprintImmunology

PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt

U. Uche, A. L. Szymczak-Workman, S. Grebinoski, A. Piccirillo, L. M. D'Cruz, L. P. Kane

This study identifies TrIP as a negative regulator of T cell activation by inhibiting PI3K, showing its role in immune response and potential as a therapeutic target.

bioRxiv · Nov 6, 2017Immunology

Tim-3 co-stimulation promotes short-term effector T cells, restricts memory precursors and is dispensable for T cell exhaustion

L. Avery, A. L. Szymczak-Workman, L. P. Kane

This study shows Tim-3 promotes short-term effector T cells and restricts memory precursors during acute infection, but is not required for T cell exhaustion.

bioRxiv · Aug 22, 2017Immunology