Author

P. Manandhar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:chicken / avian· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:non-human primate· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

R. Napit· 4 shared A. Poudel· 3 shared D. Karmacharya· 3 shared A. Basnet· 2 shared A. N. Sharma· 2 shared K. Dhital· 2 shared P. G. Rajbhandari· 2 shared S. Ghaju· 2 shared

Activity by Year

2019-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

R. Napit

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Chorography and conformational dynamism of the Soluble Human Fibrinogen in solution

M. Sen, N. E. Hudson, A. R. Offenbacher, A. T. Iavarone, Q. Nguyen, K. Ray, G. Popovic, P. Manandhar, J. E. E. Pinelo

This study presents a conformationally dynamic model of soluble human fibrinogen in solution using biophysical methods, revealing internal flexibility and a complex conformational landscape.

bioRxiv · Sep 5, 2022 · PreprintBiochemistry

Screening Avian Pathogens in Eggs from Commercial Hatcheries in Nepal- an Effective Poultry Disease Surveillance Tool

S. Sharma, K. Dhital, D. Puri, S. M. Pradhan, U. Rajbhandari, A. Basnet, S. Ghaju, P. Manandhar, N. U. Ghimire, M. K. Shahi, A. Poudel, R. Napit, D. Karmacharya

The paper screens eggs from Nepalese hatcheries for avian pathogens to detect disease outbreaks and improve surveillance.

bioRxiv · Aug 11, 2022 · PreprintMicrobiology

Identification and Characterization of Probiotics Isolates from Indigenous Chicken (Gallus domesticus) of Nepal

M. Gupta, R. Raut, S. Manandhar, A. Chaudhary, U. Shrestha, S. Dangol, S. GC, K. R. Budha, G. Karki, S. D. Sanchez, C. Gortazar, J. de la Fuente, P. G. Rajbhandari, P. Manandhar, R. Napit, D. Karmacharya

The paper isolates and characterizes potential probiotic bacteria from indigenous chickens in Nepal, identifying four Lactobacillus strains with probiotic properties.

bioRxiv · Jul 12, 2022 · PreprintMicrobiology

Newcastle disease burden in Nepal and efficacy of Tablet I-2 vaccine in commercial and backyard poultry production

R. Napit, A. Poudel, S. Pradhan, P. Manandhar, S. Ghaju, A. N. Sharma, J. Joshi, S. Tha, K. Dhital, U. Rajbhandari, A. Basnet, R. M. Rajbhandari, J. S. Schwind, D. B. Karmacharya

The paper assesses Newcastle Disease burden in Nepal and evaluates the efficacy of the I-2 vaccine in poultry, finding high sero-prevalence and identifying new NDV strains, with the vaccine showing over 85% efficacy.

bioRxiv · Jun 27, 2022 · PreprintMicrobiology

Novel strains of Campylobacter cause diarrheal outbreak in Rhesus macaques (Macaca mulatta) of Kathmandu Valley

R. Napit, P. Manandhar, A. Poudel, P. G. Rajbhandari, S. Watson, S. Shakya, S. M. Pradhan, A. N. Sharma, C. K. Johnson, J. K. Mazet, D. Karmacharya

This study identifies Campylobacter spp. as a cause of a 2018 diarrhea outbreak in Rhesus macaques in Kathmandu Valley, detecting novel strains and linking them to human and animal infections.

bioRxiv · Jun 20, 2022Microbiology

The co-stimulatory activity of Tim-3 requires Akt and MAPK signaling and immune synapse recruitment

S. Kataoka, P. Manandhar, J. Lee, C. J. Workman, H. Banerjee, A. L. Szymczak-Workman, M. Kvorjak, J. Lohmueller, L. P. Kane

This study identifies Akt and MAPK signaling as essential for Tim-3 co-stimulatory activity and shows that Tim-3 localization to the immune synapse is critical for its function.

bioRxiv · Dec 30, 2019 · PreprintImmunology