Metabolomics profiling reveals new aspects of dolichol biosynthesis in Plasmodium falciparum
F. M. Zimbres, A. L. Valenciano, E. F. Merino, N. R. Holderman, A. Florentin, G. He, K. Gawarecka, K. Skorupinska-Tudek, M. L. Fernandez-Murga, E. Swiezewska, X. Wang, V. Muralidharan, M. B. Cassera
This study uses metabolomics to show that Plasmodium falciparum has diverse and active cis-polyisoprenoid biosynthesis, including polyprenols and dolichols, with functional substitution potential.
bioRxiv · Mar 18, 2020Biochemistry