Author

V. Muralidharan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 6 Microbiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 9 Organism:human· 6 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 4 Organism:plant (other)· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:development & morphogenesis· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

A. Florentin· 6 shared D. W. Cobb· 6 shared M. A. Fierro· 5 shared C. F. Brooks· 3 shared D. Anaguano· 3 shared H. M. Kudyba· 3 shared M. Krakowiak· 3 shared A. Villegas· 2 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersMicrobiology

A. Florentin

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Plasmodium RON11 triggers biogenesis of the merozoite rhoptry pair and is essential for erythrocyte invasion

D. Anaguano, O. Adewale Fasoro, G. S. Vick, J. A. Blauwkamp, S. Yanik, M. A. Fierro, S. Absalon, P. SRINIVASAN, V. Muralidharan

This study shows that RON11 is essential for the biogenesis of the second rhoptry in Plasmodium falciparum merozoites and is required for erythrocyte invasion.

bioRxiv · Jan 29, 2024Cell Biology

Rapid, time-resolved proximity labeling by SBP1 identifies a porin domain protein at the malaria parasite periphery

D. Anaguano, C. F. Brooks, D. W. Cobb, V. Muralidharan

This study uses SBP1TbID to identify proteins involved in exporting membrane proteins from the malaria parasite periphery.

Journal of Cell Science · Oct 15, 2023Peer-reviewedCell Biology

Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy

B. Liffner, A. K. Cepeda Diaz, J. Blauwkamp, D. Anaguano, S. Frolich, V. Muralidharan, D. W. Wilson, J. Dvorin, S. Absalon

This study uses ultrastructural expansion microscopy to analyze the 3D organization of Plasmodium falciparum during intraerythrocytic development, revealing new insights into organelle biogenesis and cell biology.

bioRxiv · Mar 22, 2023 · PreprintCell Biology

A druggable oxidative folding pathway in the endoplasmic reticulum of human malaria parasites

D. W. Cobb, H. M. Kudyba, A. Villegas, M. R. Hoopmann, R. Baptista, B. Bruton, M. Krakowiak, R. L. Moritz, V. Muralidharan

This study identifies a druggable oxidative folding pathway in the ER of P. falciparum, showing that PfPDI8 is essential and sensitive to small molecule inhibition.

bioRxiv · May 13, 2020Microbiology

Metabolomics profiling reveals new aspects of dolichol biosynthesis in Plasmodium falciparum

F. M. Zimbres, A. L. Valenciano, E. F. Merino, N. R. Holderman, A. Florentin, G. He, K. Gawarecka, K. Skorupinska-Tudek, M. L. Fernandez-Murga, E. Swiezewska, X. Wang, V. Muralidharan, M. B. Cassera

This study uses metabolomics to show that Plasmodium falciparum has diverse and active cis-polyisoprenoid biosynthesis, including polyprenols and dolichols, with functional substitution potential.

bioRxiv · Mar 18, 2020Biochemistry

The Clp System in Malaria Parasites Degrades Essential Substrates to Regulate Plastid Biogenesis

A. Florentin, D. R. Stephens, C. F. Brooks, R. P. Baptista, V. Muralidharan

This study identifies the role of the Clp protease system in regulating apicoplast biogenesis in Plasmodium falciparum by demonstrating its enzymatic activity and interactions with chaperones and substrates.

bioRxiv · Nov 4, 2019Microbiology

An ER CREC family protein regulates the egress proteolytic cascade in malaria parasites

M. A. Fierro, B. Asady, C. F. Brooks, A. Villegas, S. N. J. Moreno, V. Muralidharan

This study identifies PfERC, an ER-resident CREC family protein, as essential for the proteolytic cascade regulating egress in malaria parasites.

bioRxiv · Jul 31, 2019 · PreprintCell Biology

The ER chaperone PfGRP170 is essential for asexual development and is linked to stress response in malaria parasites.

H. M. Kudyba, D. W. Cobb, M. A. Fierro, A. Florentin, D. Ljolje, B. Singh, N. W. Lucchi, V. Muralidharan

This study identifies PfGRP170 as an essential ER chaperone in Plasmodium falciparum, critical for asexual development and stress response.

bioRxiv · Apr 17, 2019Cell Biology

CRISPR/Cas9 gene editing to make conditional mutants of the human malaria parasite Plasmodium falciparum

H. M. Kudyba, D. W. Cobb, A. Florentin, M. Krakowiak, V. Muralidharan

This paper describes a CRISPR/Cas9 method for generating conditional knockdown mutants in Plasmodium falciparum, enabling genetic manipulation of the malaria parasite.

bioRxiv · May 15, 2018Cell Biology

The exported chaperone PfHsp70x is dispensable for the Plasmodium falciparum intraerythrocytic lifecycle

D. W. Cobb, A. Florentin, M. A. Fierro, M. Krakowiak, J. M. Moore, V. Muralidharan

This study shows that PfHsp70x, the sole exported Hsp70 in P. falciparum, is not essential for parasite growth or protein export during the intraerythrocytic lifecycle.

bioRxiv · Aug 11, 2017Microbiology

PfClpC Is An Essential Clp Chaperone Required For Plastid Integrity And Clp Protease Stability In Plasmodium falciparum

A. Florentin, D. W. Cobb, J. D. Fishburn, M. J. Cipriano, P. S. Kim, M. A. Fierro, B. Striepen, V. Muralidharan

This paper identifies PfClpC as an essential apicoplast-targeted chaperone in Plasmodium falciparum, showing its role in maintaining apicoplast integrity and parasite viability.

bioRxiv · Jun 20, 2017Microbiology