Author

M. L. Littlehale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:E. coli· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

M. T. Laub· 3 shared G. Teodoro· 2 shared M. LeRoux· 2 shared A. Leung· 1 shared C. Doering· 1 shared C. Vassallo· 1 shared M. Badiee· 1 shared P. Culviner· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersMicrobiology

M. T. Laub

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Author profile →

3 papers

Recent·Most cited

Mapping the landscape of anti-phage defense mechanisms in the E. coli pangenome

C. Vassallo, C. Doering, M. L. Littlehale, G. Teodoro, M. T. Laub

The paper identifies 21 new conserved defense systems in E. coli strains, showing that prophages and mobile elements are key reservoirs of antiviral immunity.

bioRxiv · May 12, 2022 · PreprintMicrobiology

The DarTG toxin-antitoxin system provides phage defense by ADP-ribosylating viral DNA

M. LeRoux, S. Srikant, M. L. Littlehale, G. Teodoro, S. Doron, M. Badiee, A. Leung, R. Sorek, M. T. Laub

This study identifies DarTG toxin-antitoxin systems in E. coli that defend against phage by ADP-ribosylating viral DNA, with phages evolving resistance through DNA polymerase or anti-DarT factors.

bioRxiv · Sep 27, 2021 · PreprintMicrobiology

Stress induces the transcription of toxin-antitoxin systems but does not activate toxin

M. LeRoux, P. Culviner, Y. J. Liu, M. L. Littlehale, M. T. Laub

The paper shows stress increases TA system transcription but does not release toxin, suggesting TA systems may not promote stress survival.

bioRxiv · Mar 2, 2020 · PreprintMicrobiology