Tuberculosis treatment failure associated with evolution of antibiotic resilience
Q. Liu, J. Zhu, C. L. Dulberger, S. Stanley, S. Wilson, E. S. Chung, X. Wang, P. Culviner, Y. J. Liu, N. D. Hicks, G. H. Babunovic, S. R. Giffen, B. B. Aldridge, E. C. Garner, E. J. Rubin, , S. M. Fortune
The paper identifies resR as a target of positive selection in Mtb clinical isolates, linking its mutations to antibiotic resilience and treatment failure.
bioRxiv · Mar 29, 2022Microbiology