Author

M. L. Santiago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Assay:flow cytometry· 1

Frequent Co-Authors

K. Sutter· 3 shared M. Widera· 3 shared U. Dittmer· 3 shared B. S. Barrett· 2 shared C. Elsner· 2 shared F. Roesmann· 2 shared H. Sertznig· 2 shared K. Guo· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

K. Sutter

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cellular hnRNPA0 limits HIV-1 production by interference with LTR-activity and programmed ribosomal frame-shifting

F. Roesmann, H. Sertznig, K. Klaassen, A. Wilhelm, D. Heininger, C. Elsner, M. L. Santiago, S. Esser, K. Sutter, U. Dittmer, M. Widera

This study shows hnRNPA0 limits HIV-1 replication by inhibiting LTR activity and ribosomal frameshifting, with lower expression in HIV-infected individuals.

bioRxiv · Aug 8, 2023 · PreprintMicrobiology

Interferon-α subtype treatment induces the repression of SRSF1 in HIV-1 target cells and affects HIV-1 post integration steps

H. Sertznig, F. Roesmann, B. Bleekmann, C. Elsner, M. L. Santiago, J. Schuhenn, Y. Benatzy, R. Snodgrass, S. Esser, K. Sutter, U. Dittmer, M. Widera

This study shows that IFN-α treatment represses SRSF1 in HIV-1 target cells, affecting post-integration viral replication steps by altering splicing and transcription.

bioRxiv · Jun 11, 2021 · PreprintMicrobiology

Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques

K. J. Hasenkrug, F. Feldmann, L. Myers, M. L. Santiago, K. Guo, B. S. Barrett, K. L. Mickens, A. Carmody, A. Okumura, D. Rao, M. M. Collins, R. J. Messer, J. Lovaglio, C. Shaia, R. Rosenke, , H. Feldmann

This study shows that T cell depletion in rhesus macaques does not cause severe SARS-CoV-2 disease but delays viral clearance, and T cells are not essential for immunological memory or protection against re-infection.

bioRxiv · Apr 2, 2021Immunology

Interferon Resistance of Emerging SARS-CoV-2 Variants

K. Guo, B. S. Barrett, K. L. Mickens, E. K. Vladar, J. H. Morrison, K. J. Hasenkrug, E. M. Poeschla, M. L. Santiago

This study shows emerging SARS-CoV-2 variants are more resistant to human interferons, suggesting innate immune evasion plays a key role in their evolution.

bioRxiv · Mar 20, 2021Microbiology

HIV infection does not alter Interferon α/β receptor expression on mucosal immune cells

J. Ickler, S. Francois, M. Widera, M. L. Santiago, U. Dittmer, K. Sutter

This study investigates whether HIV infection alters IFNAR2 expression on mucosal immune cells and finds no significant changes in IFNAR2 expression in HIV+ patients or after HIV-1 infection ex vivo.

bioRxiv · Jul 2, 2019Immunology