A. Okumura

Transmission dynamics of MERS-CoV in a transgenic human DPP4 mouse model

This study demonstrates limited MERS-CoV transmission via aerosol, fomite, and direct contact in a transgenic human DPP4 mouse model.

A bivalent Adenovirus-Vectored Vaccine induces a measurable humoral response, but does not protect cynomolgus macaques against a lethal challenge with Sudan virus

This study evaluates a bivalent Adenovirus-Vectored Vaccine in cynomolgus macaques against Sudan virus, finding it induces humoral responses but does not confer protection against lethal challenge.

Rectal and vaginal challenge with mpox virus increases virus dissemination and contact transmission compared to skin challenge in the multimammate rat (Mastomys natalensis)

This study shows that rectal and vaginal mpox virus inoculation in rats leads to more virus shedding and contact transmission compared to skin inoculation.

SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta

This study compares disease severity and viral load in rhesus macaques infected with SARS-CoV-2 Delta, Omicron BA.1, and BA.2 variants, finding Omicron variants cause less severe disease with lower viral loads.

Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques

The combination of molnupiravir and nirmatrelvir inhibits SARS-CoV-2 replication and shedding more effectively than individual treatments in the rhesus macaque model.

Molnupiravir (MK-4482) is efficacious against Omicron and other SARS-CoV-2 variants in the Syrian hamster COVID-19 model

MK-4482 inhibits replication of multiple SARS-CoV-2 variants of concern, including Omicron, in the Syrian hamster model.

Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques

This study compares immune dynamics in young and old rhesus macaques infected with SARS-CoV-2, finding age-related differences in post-acute immune responses but similar acute disease outcomes.

ChAdOx1 NiV vaccination protects against lethal Nipah Bangladesh virus infection in African green monkeys

ChAdOx1 NiV vaccination protects African green monkeys from lethal Nipah virus infection, preventing disease signs and viral replication.

UK B.1.1.7 variant exhibits increased respiratory replication and shedding in nonhuman primates

This study compares the respiratory replication and shedding of SARS-CoV-2 D614G and B.1.1.7 variants in African green monkeys, finding increased respiratory replication for B.1.1.7 but no disease enhancement.

Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaques

This study compares the pathogenicity of SARS-CoV-2 variants B.1.1.7 and B.1.351 in rhesus macaques, finding differences in clinical outcomes and immune responses.

Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques

This study shows that T cell depletion in rhesus macaques does not cause severe SARS-CoV-2 disease but delays viral clearance, and T cells are not essential for immunological memory or protection against re-infection.

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

A single intranasal dose of ChAd-SARS-CoV-2-S vaccine protects against SARS-CoV-2 infection in rhesus macaques by inducing neutralizing antibodies and T cell responses.

Rapid protection from COVID-19 in nonhuman primates vaccinated intramuscularly but not intranasally with a single dose of a recombinant vaccine

A single-dose VSV-based vaccine protected nonhuman primates from COVID-19 within 10 days when administered intramuscularly but not intranasally.

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques

This study shows intranasal ChAdOx1 nCoV-19 vaccination reduces SARS-CoV-2 shedding in animal models but not pneumonia protection.

Immunocompetent Mouse Model for Crimean-Congo Hemorrhagic Fever Virus

This paper develops an immunocompetent mouse model for CCHFV that replicates human disease severity, enabling better study of host-viral interactions.

Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection

The paper shows Syrian hamsters are highly susceptible to SARS-CoV-2, making them a suitable model for developing countermeasures against COVID-19.

SARS-CoV-2 infection dynamics in lungs of African green monkeys

This study examines SARS-CoV-2 infection dynamics in African green monkeys, showing viral replication in the lower respiratory tract and macrophage involvement in inflammation.

Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2

This study shows hydroxychloroquine does not reduce SARS-CoV-2 replication or improve clinical outcomes in hamsters or macaques.

ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques

This study shows that the ChAdOx1 nCoV-19 vaccine reduces SARS-CoV-2 viral load and prevents pneumonia in rhesus macaques without causing immune-enhanced disease.

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

This study shows remdesivir reduces SARS-CoV-2 viral load and lung damage in rhesus macaques when administered early in infection.

A single dose of ChAdOx1 MERS provides broad protective immunity against a variety of MERS-CoV strains

A single dose of ChAdOx1 MERS vaccine protects rhesus macaques and mice against MERS-CoV infection and multiple strains.

Respiratory disease and virus shedding in rhesus macaques inoculated with SARS-CoV-2

This study shows that SARS-CoV-2 causes respiratory disease in rhesus macaques with symptoms similar to human cases, including prolonged viral shedding.