H. Feldmann

Compartmentalized SARS-CoV-2 replication in upper versus lower respiratory tract after intranasal inoculation or aerosol exposure

This study compares SARS-CoV-2 replication in rhesus macaques after intranasal inoculation or aerosol exposure, finding differences in respiratory tract involvement.

Rectal and vaginal challenge with mpox virus increases virus dissemination and contact transmission compared to skin challenge in the multimammate rat (Mastomys natalensis)

This study shows that rectal and vaginal mpox virus inoculation in rats leads to more virus shedding and contact transmission compared to skin inoculation.

VSV-based vaccine provides species-specific protection against Sudan virus challenge in macaques

This study develops a VSV-based vaccine against Sudan virus and shows it protects macaques from lethal infection, highlighting the need for specific countermeasures against filoviruses.

Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques

The combination of molnupiravir and nirmatrelvir inhibits SARS-CoV-2 replication and shedding more effectively than individual treatments in the rhesus macaque model.

A replicon RNA vaccine induces durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned

This study shows a replicon RNA vaccine provides durable protection against SARS-CoV-2 in nonhuman primates even after neutralizing antibodies decline.

SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta

This study compares disease severity and viral load in rhesus macaques infected with SARS-CoV-2 Delta, Omicron BA.1, and BA.2 variants, finding Omicron variants cause less severe disease with lower viral loads.

Molnupiravir (MK-4482) is efficacious against Omicron and other SARS-CoV-2 variants in the Syrian hamster COVID-19 model

MK-4482 inhibits replication of multiple SARS-CoV-2 variants of concern, including Omicron, in the Syrian hamster model.

Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease and pathology and reduce viral shedding following challenge with heterologous SARS-CoV2 variants of concern

This study evaluates a replicating RNA vaccine against SARS-CoV-2 variants, showing protection from disease and reduced viral shedding after heterologous challenge.

UK B.1.1.7 variant exhibits increased respiratory replication and shedding in nonhuman primates

This study compares the respiratory replication and shedding of SARS-CoV-2 D614G and B.1.1.7 variants in African green monkeys, finding increased respiratory replication for B.1.1.7 but no disease enhancement.

Ebola virus glycoprotein domains associated with protective efficacy

The paper identifies regions of the Ebola virus glycoprotein that are essential for vaccine vector replication but not for protective immunity.

Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques

This study shows that T cell depletion in rhesus macaques does not cause severe SARS-CoV-2 disease but delays viral clearance, and T cells are not essential for immunological memory or protection against re-infection.

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

A single intranasal dose of ChAd-SARS-CoV-2-S vaccine protects against SARS-CoV-2 infection in rhesus macaques by inducing neutralizing antibodies and T cell responses.

Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in COPD

This study shows that goblet cells in COPD patients are more susceptible to SARS-CoV-2 infection due to higher ACE2 and TMPRSS2 expression, leading to increased viral replication.

Immunocompetent Mouse Model for Crimean-Congo Hemorrhagic Fever Virus

This paper develops an immunocompetent mouse model for CCHFV that replicates human disease severity, enabling better study of host-viral interactions.

Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers.

This study evaluates peptide-conjugated morpholino oligomers (PPMO) against SARS-CoV-2 in Vero cells, showing significant viral titer reduction without toxicity.

Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection

The paper shows Syrian hamsters are highly susceptible to SARS-CoV-2, making them a suitable model for developing countermeasures against COVID-19.

SARS-CoV-2 infection dynamics in lungs of African green monkeys

This study examines SARS-CoV-2 infection dynamics in African green monkeys, showing viral replication in the lower respiratory tract and macrophage involvement in inflammation.

Susceptibility of swine cells and domestic pigs to SARS-CoV-2

This study assesses SARS-CoV-2 susceptibility in swine cells and pigs, finding replication in cell lines but no infection or transmission in pigs.

Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2

This study shows hydroxychloroquine does not reduce SARS-CoV-2 replication or improve clinical outcomes in hamsters or macaques.

Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates

Prior vaccination with the rVSV-ZEBOV vaccine does not interfere with but improves the efficacy of postexposure antibody treatment in nonhuman primates exposed to Ebola virus