Intranasal Vaccination with a Lentiviral Vector Strongly Protects against SARS-CoV-2 in Mouse and Golden Hamster Preclinical Models
M.-W. Ku, M. Bourgine, P. Authie, J. Lopez, K. Nemirov, F. Moncoq, A. Noirat, B. Vesin, F. Nevo, C. Blanc, P. Souque, H. Tabbal, E. Simon, M. Le Dudal, F. Guinet, , P. Charneau
This study shows that intranasal vaccination with a lentiviral vector encoding the SARS-CoV-2 Spike protein provides strong protection against SARS-CoV-2 in mice and golden hamsters by reducing viral load and inflammation.
bioRxiv · Jul 21, 2020 · PreprintImmunology