P. Charneau

Mice Humanized for Major Histocompatibility Complex and Angiotensin-Converting Enzyme 2 with High Permissiveness to SARS-CoV-2 Omicron Replication

This paper develops hACE2 transgenic mice with high permissiveness to SARS-CoV-2 Omicron replication and uses them to test a vaccine candidate.

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

An intranasal lentiviral booster broadens immune recognition of SARS-CoV-2 variants and reinforces the waning mRNA vaccine-induced immunity that it targets to lung mucosa

This study shows an intranasal lentiviral booster enhances and broadens immune response to SARS-CoV-2 variants and improves waning mRNA vaccine immunity in the lungs.

Full Brain and Lung Prophylaxis against SARS-CoV-2 by Intranasal Lentiviral Vaccination in a New hACE2 Transgenic Mouse Model or Golden Hamsters

This study shows that an intranasal lentiviral vaccine protects both the respiratory and central nervous systems against SARS-CoV-2 in a new hACE2 transgenic mouse model.

Intranasal Vaccination with a Lentiviral Vector Strongly Protects against SARS-CoV-2 in Mouse and Golden Hamster Preclinical Models

This study shows that intranasal vaccination with a lentiviral vector encoding the SARS-CoV-2 Spike protein provides strong protection against SARS-CoV-2 in mice and golden hamsters by reducing viral load and inflammation.

Remodeling of the core leads HIV-1 pre-integration complex in the nucleus of human lymphocytes.

This study reveals how HIV-1 CA proteins remodel into a 'pearl necklace' structure around viral DNA to facilitate nuclear entry in human lymphocytes.