M. Liu

The paper analyzes gene panel sequencing data from 829 Chinese high-risk breast cancer patients to identify pathogenic variants and variants of uncertain significance across 115 hereditary cancer susceptibility genes.

The paper shows that APBs function as liquid condensates that cluster telomeres through liquid properties, supporting the ALT pathway in telomerase-free cancer cells.

This study identifies fragment molecules targeting tankyrase's substrate-binding ankyrin repeat domains through biophysical assays, offering potential new therapeutic approaches for cancer.

The paper analyzes whole-genome sequences of 16 ExPEC ST73 isolates from a single hospital to identify circulating clonal groups and their mobile genetic elements.

This study identifies surface proteins of Lactobacillus pentosus HC-2 as essential for its probiotic effects in shrimp midgut using proteomic analysis.

The paper visualizes replication foci during S-phase and reveals a CTCF-dependent hierarchical radial propagation pattern that reverses directionality over time.

The paper identifies CDO1 as a metabolic liability in NSCLC by showing its silencing promotes proliferation through cysteine metabolism disruption.

This study shows that B1a cells reduce liver inflammation and fibrosis in Schistosoma japonicum infection by secreting IL-10, which suppresses monocyte infiltration and inflammatory cytokines.

This study shows that interspecific competition with blowflies triggers cooperation in burying beetles through a chemical cue, dimethyl disulfide.

The paper identifies a hypoxia-specific metabolic pathway in cancer cells that redirects glutamine nitrogen to secretory dihydroorotate, avoiding ammonia toxicity and supporting tumor growth.

This paper shows that transmural mean hoop stress of the aortic wall can be calculated from in vivo images using thin-walled models without needing patient-specific material properties or residual deformations.

This paper develops a machine learning approach to estimate aortic wall constitutive parameters from 3D geometries at different blood pressure levels, improving efficiency over traditional inverse methods.

This study shows that chemical-mediated interactions, particularly growth-facilitating influences and self-restraint, promote microbial coexistence in communities.

The paper presents the structure of human TRPC6 ion channel in complex with inhibitor BTDM, revealing its architecture and inhibition mechanism.

This study identifies WDR45's role in neurodegeneration by showing its regulation of ER homeostasis and neuronal death through autophagy defects.

This study uses deep learning to estimate collagenous tissue mechanical properties from microscopy images with high accuracy.