M. Liu

This paper investigates the ligand recognition mechanism of PHF20L1 Tudor1, revealing a pre-existing open conformation that enables binding to both methylated proteins and small molecules.

This study shows that filamentous viral particles have a functional advantage over spherical ones in resisting neutralizing antibodies and fusion inhibitors.

This study compares 50 Claviceps genomes to show how genome plasticity and transposable elements drive host range expansion and adaptability in fungal pathogens.

This study shows that pattern-recognition receptors (PRRs) are essential for NLR-mediated immunity in plants, revealing a unified model where PTI supports ETI during bacterial infection.

The paper reports the cryo-ET structure of the luminal ring of the Xenopus laevis nuclear pore complex and identifies key structural features confirmed by cryo-EM.

The paper presents a high-resolution cryo-EM structure of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing new structural features and interactions.

The paper identifies genetic signatures in tumor microenvironments to explain resistance to immunotherapy and suggests potential therapeutic strategies.

The paper identifies molecular signatures of inflamed and non-inflamed tumor microenvironments across cancers and suggests potential drugs to convert non-inflamed tumors to inflamed ones.

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

This study identifies IRF8 as a key factor in tumor-associated macrophages (TAMs) that induce T cell exhaustion by presenting cancer antigens, and shows its association with poor patient survival in renal cell carcinoma.

This paper identifies EK1C4, a potent fusion inhibitor against SARS-CoV-2 and other coronaviruses, showing high efficacy in vitro and in vivo.

This study shows that blocking TGFβ signaling in CD4+ T cells enhances type 2 immunity, promoting tumor healing and halting cancer progression through IL-4-mediated vasculature repair.

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

The paper uses theoretical models to show coordinated specialisation is more adaptive than random specialisation in microorganisms under certain environmental conditions.

The paper identifies 3,763 SUMO1 modification sites and their dependence on six SENP proteins, revealing SENP3's role in innate immunity through deSUMOylation of DHX15 and PCBP2.

This study identifies SYP12 syntaxins in Arabidopsis as essential for forming papillae and encasements, which mediate broad pre-invasive immunity against non-adapted filamentous pathogens.

This study shows that anethole dithiolethione improves liver fatty acid metabolism in hamsters on high-fat diets by altering fatty acid profiles and regulating key metabolic pathways.

The paper analyzes gut microbiome data from 946 donors to show age-related changes in bacterial profiles and links them to immune traits, supporting personalized microbial therapeutics.

This study identifies a conserved proinsulin interactome in human islets, revealing PRDX4's role in proinsulin folding and its inactivation in T2D.

The paper detects hydrogen evolution and absorption in plasma membrane vesicles of higher plants using spectrophotometry, gas chromatography, and H2 sensors, revealing bidirectional H2 activity.

The paper develops a method to measure multiscale chromatin folding and nuclear structures in single cells, revealing cell-type-specific architectures and physical principles of chromatin organization.

This paper characterizes an ammonia-tolerant ammonia-oxidizing archaeon from vegetable soil, identifying genomic and physiological mechanisms underlying its high ammonia tolerance.

This study shows PHGDH depletion in adult mice is tolerated, with normal liver and pancreatic function, but reduced PHGDH leads to altered lipid homeostasis in the liver.

A CGMMV-based vector enables gene function studies in cucurbits, an extremely low efficiency species for genetic transformation.

This study identifies proinsulin self-association as a mechanism driving dominant-negative effects of misfolded proinsulin in MIDY, offering a therapeutic target for enhancing insulin production.

This study constructs large-scale, morphologically controlled λ-DNA networks using a DC electric field and investigates factors affecting their structure.

This study shows that CHL1 overexpression reverses chemoresistance to cisplatin and paclitaxel in lung cancer by inhibiting the Akt pathway.

The paper investigates the thermal insulation properties of diagonal-braced wood frame walls but was removed due to an error.

This study identifies Di-Ras2 as an oncogene in ccRCC that promotes tumor formation by activating the MAPK pathway in the absence of VHL.