Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter
C. D. Kinz-Thompson, M. Lopez Redondo, C. Mulligan, D. B. Sauer, J. J. Marden, J. Song, E. Tajkhorshid, J. F. Hunt, D. L. Stokes, J. A. Mindell, D.-N. Wang, R. L. Gonzalez
This study uses single-molecule experiments to show that VcINDY, a sodium-coupled dicarboxylate transporter, uses stochastic elevator-like motions for substrate translocation, with non-cooperative protomer movements and cooperative binding.
bioRxiv · May 1, 2022Biophysics