C. D. Kinz-Thompson

Increasing the accuracy of single-molecule data analysis using tMAVEN

This paper introduces tMAVEN, a software platform for analyzing single-molecule data using multiple kinetic models to improve accuracy by addressing mismatches between models and molecular mechanisms.

The mechanism of mRNA activation

This study uses single-molecule fluorescence imaging to investigate how eIF4F recognizes and activates mRNA caps, revealing allosteric communication and subunit functions in the process.

Biomolecular Resolution as a Quantification of Structural Information Content

This paper introduces a new resolution metric for structural biology that quantifies how effectively biomolecular structural information is captured across different length scales.

Mechanistic implications of the interaction of the soluble substrate-binding protein with a type II ABC importer

The paper investigates the interaction kinetics of the SBP with a type II ABC importer using FRET, revealing a locked complex formation that requires ATP hydrolysis and is inhibited by ATP or B12 binding.

Realtime observation of ATP-driven single B12 molecule translocationthrough BtuCD-F

This study uses smFRET to observe real-time ATP-driven translocation of B12 through the E. coli BtuCD-F transporter, revealing two sequential conformational changes.

Entropic control of the free energy landscape of an archetypal biomolecular machine

This study reveals how ligands modulate the free energy landscape of the bacterial ribosome by altering its structural flexibility, suggesting entropic control as a general mechanism for regulating biomolecular machines.

Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter

This study uses single-molecule experiments to show that VcINDY, a sodium-coupled dicarboxylate transporter, uses stochastic elevator-like motions for substrate translocation, with non-cooperative protomer movements and cooperative binding.

Bayesian inference: The comprehensive approach to analyzing single-molecule experiments

The paper explains how Bayesian inference provides a comprehensive framework for analyzing single-molecule experiments by rigorously accounting for uncertainties and integrating multiple experiments.

Increasing the time resolution of single-molecule experiments with Bayesian inference

This paper introduces a Bayesian inference method to enhance time resolution in single-molecule experiments by inferring faster dynamics than the experimental technique can capture.