Author

J. J. Marden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. Mulligan· 2 shared D.-N. Wang· 2 shared J. Song· 2 shared C. D. Kinz-Thompson· 1 shared D. B. Sauer· 1 shared D. L. Stokes· 1 shared D. Sauer· 1 shared E. Tajkhorshid· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiophysics

C. Mulligan

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Author profile →

2 papers

Recent·Most cited

Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter

C. D. Kinz-Thompson, M. Lopez Redondo, C. Mulligan, D. B. Sauer, J. J. Marden, J. Song, E. Tajkhorshid, J. F. Hunt, D. L. Stokes, J. A. Mindell, D.-N. Wang, R. L. Gonzalez

This study uses single-molecule experiments to show that VcINDY, a sodium-coupled dicarboxylate transporter, uses stochastic elevator-like motions for substrate translocation, with non-cooperative protomer movements and cooperative binding.

bioRxiv · May 1, 2022Biophysics

Structural basis of ion - substrate coupling in the Na+-dependent dicarboxylate transporter VcINDY

D. Sauer, J. J. Marden, J. C. Sudar, J. Song, C. Mulligan, D.-N. Wang

This study reveals the structural mechanism by which VcINDY couples sodium and substrate binding through an induced-fit mechanism, showing that sodium binding stabilizes the substrate binding site.

bioRxiv · Jan 11, 2022Biophysics