RNA matchmaking remodels lncRNA structure and promotes PRC2 activity
M. M. Balas, E. W. Hartwick, C. Barrington, J. T. Roberts, S. K. Wu, R. Bettcher, A. M. Griffin, J. S. Kieft, A. M. Johnson
The paper shows that RNA matchmaking between HOTAIR and target gene RNAs relieves PRC2 inhibition, promoting its activity through structural changes and hnRNP B1-mediated interactions.
bioRxiv · Apr 13, 2020 · PreprintBiochemistry