Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry
S. Y. Kim, W. Jin, A. Sood, D. W. Montgomery, O. C. Grant, M. M. Fuster, L. Fu, J. S. Dordick, R. J. Woods, F. Zhang, R. J. Linhardt
This study identifies a glycosaminoglycan-binding motif in SARS-CoV-2 spike glycoprotein that enhances binding to heparin, suggesting a role in host cell entry and potential for carbohydrate-based therapies.
bioRxiv · Apr 14, 2020 · PreprintBiochemistry