O. C. Grant

Hyper-Truncated Glycans Augment the Activity of Neutrophil Granule Myeloperoxidase

This study identifies hyper-truncated glycans on neutrophil myeloperoxidase (MPO) that enhance enzyme activity and inhibition potential, revealing their functional role in immune responses.

PD-L1 glycosylation and its impact on binding to clinical antibodies

This study investigates PD-L1 glycosylation patterns and their impact on interactions with PD-1 and clinical antibodies, revealing site-specific glycan structures and potential functional implications.

Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor

The paper characterizes glycosylation of SARS-CoV-2 Spike and ACE2 using glycomics and simulations to understand their interactions and guide immunogen design.

Landscape and Selection of Vaccine Epitopes in SARS-CoV-2

This study identifies vaccine epitopes in SARS-CoV-2 by combining computational T cell epitope prediction, B cell epitope mapping, and manufacturability criteria to propose candidate peptides for further testing.

Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry

This study identifies a glycosaminoglycan-binding motif in SARS-CoV-2 spike glycoprotein that enhances binding to heparin, suggesting a role in host cell entry and potential for carbohydrate-based therapies.

Analysis of the SARS-CoV-2 spike protein glycan shield: implications for immune recognition

The paper analyzes SARS-CoV-2 spike protein glycan structures and their impact on immune recognition, finding that glycans extensively shield the protein surface from antibodies.

Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor

This study investigates how the CI-MPR receptor binds and releases carbohydrates through allosteric domain cooperativity using biophysical methods and crystal structures.